Plectrocliemica[ and%erma[ Studies on Some P[uoroquinofones

Abstract

This work has been carried out to investigate the electrochemical micro detennination of lomefloxacin (LFX), sparfloxacin (SFX), gatifloxacin (GFX) ,and moxifloxacin (MFX) through oxidation reaction at carbon paste electrode in acetate buffer of pH 5, and reduction reaction at hanging mercury dropping electrode HMDE in Britton-Robinson Buffer. Pd(ll)-4- quinolone complexes were prepared and identified through the modification of the direct HMDE method. -These three methods were applied for detennination of the investigated drugs in raw materials, phannaceutical preparations, and biological fluids. -Solid state study of the cited drugs through thennal analysis techniques TG and DTA, was carried out. The kinetic and activation parameters were calculated and the order of stability was found to be LFX > SFX > GFX > MFX. The DSC method was found to be suitable for the detennination of the investigated drugs. Some thennal parameters were also calculated using Arrhinus and Ozawa methods.