Soluble Lectin like Oxidized LDL Receptor-1 (sLOX-1): A Recent Marker for Prediction of High Risk CAD Patients
Ola Aboutaleb OthmanYounis;
Abstract
C
oronary artery diseases (CAD), also known as ischemic heart diseases, are diverse, with a spectrum that comprises various forms of angina pectoris, acute myocardial infarction (AMI), and sudden cardiac death. They are the leading cause of death among adults and one of the most common reasons for emergency department visits worldwide.
Like many cell surface receptors with a single transmembrane domain, LOX-1 can convert into soluble molecules by proteolytic cleavage at its membrane proximal extracellular domain. Circulating soluble LOX-1 (sLOX-1) levels may reflect the expression of LOX-1 and are associated with inflammatory and oxidative stress markers in patients with CAD. Moreover, circulating sLOX-1 levels are elevated in patients with acute coronary syndrome (ACS), which may reflect its prominent expression and enhance protease activities in vulnerable atherosclerotic plaques in situ.
In this regard, our study aimed to evaluate the role of increase sLOX-1 level as a diagnostic and prognostic tool in patients with CAD and to correlate its values with coronary angiography results. Additionally, the role of sLOX-1 results was compared to other traditional dyslipidemic risk factors for CAD.
This study was conducted on fifty patients und
oronary artery diseases (CAD), also known as ischemic heart diseases, are diverse, with a spectrum that comprises various forms of angina pectoris, acute myocardial infarction (AMI), and sudden cardiac death. They are the leading cause of death among adults and one of the most common reasons for emergency department visits worldwide.
Like many cell surface receptors with a single transmembrane domain, LOX-1 can convert into soluble molecules by proteolytic cleavage at its membrane proximal extracellular domain. Circulating soluble LOX-1 (sLOX-1) levels may reflect the expression of LOX-1 and are associated with inflammatory and oxidative stress markers in patients with CAD. Moreover, circulating sLOX-1 levels are elevated in patients with acute coronary syndrome (ACS), which may reflect its prominent expression and enhance protease activities in vulnerable atherosclerotic plaques in situ.
In this regard, our study aimed to evaluate the role of increase sLOX-1 level as a diagnostic and prognostic tool in patients with CAD and to correlate its values with coronary angiography results. Additionally, the role of sLOX-1 results was compared to other traditional dyslipidemic risk factors for CAD.
This study was conducted on fifty patients und
Other data
| Title | Soluble Lectin like Oxidized LDL Receptor-1 (sLOX-1): A Recent Marker for Prediction of High Risk CAD Patients | Other Titles | مستقبل أشباه اللكتين المؤكسدهللدهون البروتينية منخفضة الكثافة الذائب-1 دلالة حديثة للتنبؤ بمرضى قصور الشريان التاجى ذوى الخطورة الكبرى | Authors | Ola Aboutaleb OthmanYounis | Issue Date | 2014 |
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