Comparative Study Of The Value Of Cervico­ Vaginal Interleukin-8 And Fetal Fibronectin In Prediction Of Prematurity In Twins

Abstract

The objectives of this study were to evaluate both interleukin-8 and fetal fibronectin in cervico-vaginal secretion of women pregnant in twins as a predictors of preterm delivery and to compare the diagnostic value of interleukin-8 and fetal fibronectin in predicting preterm delivery. Interleukin-8 and fetal fibronectin were assayed in cervico-vaginal secretions in 120 women pregnant in twins between 28-40 gestational weeks. They were divided into 4 groups (A) 30 patients were premature not in labor (PMNIL) (B) 30 patients were mature not in labor (MNIL) (C) 30 patients were premature in labor (PMIL) (D) 30 patients were mature in labor (MIL).

Interleukin-8 was significantly increased were gestational age increase. Both interleukin-8 and fetal fibronectin were significantly higher in (PMIL) than in (PMNIL) and were significantly higher in (MIL) than in (MNIL).

In conclusion, increased concentrations of interleukin-8 and fetal fibronectin contribute to mature and premature delivery and their diagnostic value seems comparable.