Monitoring Circulating Regulatory T Cells during the Early Post transplant Period in Kidney Transplantation in Egypt

Abstract

Chronic kidney disease is a world wide public health issue. Renal failure disease is considered as a public article in chronic kidney disease. CRF mean the kidney lose ability to perform their function. In Egypt, 200 new cases per million inhabitants every year according to official statistical reports, the CRF can be cured with dialysis and transplantation. Although kidney transplantation considered as an efficient treatment, the major hurdle to kidney transplantation lies in rejected recipients` (patients`) body for the kidney transplanted from donors due to immune system by recognized on self constituent of the body and non-self antigens. The control of the kidney transplant rejection depends largely on early detection and the treatment with suitable immunosuppression drugs, the rejection divided to 3 types acute rejection, hyperacute rejection and chronic rejection. Despite the availability of more potent immunosuppression, the incidence of rejection continues to be an important cause of graft loss. A definite diagnosis for kidney transplant acute rejection can be made by histologically characterized by tubulointerstitial mononuclear Summary & conclusion 128 infiltration identified from a biopsy specimen and considered as “gold standard” but core needle biopsy is an invasive technique and is not risk free. All major complications after needle biopsy manifest as perinephric or urinary bleeding macroscopic hematuria follows about 3% of biopsies and may prolong hospitalization or lead to blood transfusion or placement of a bladder catheter for clot drainage.