EFIFECT OF TAMOXIFEN ON SEX HORMONES AND LIPID PROFILES IN PATIENTS WITH BREAST CANCER
ADEL MOHAMED SHENDY;
Abstract
In this study, Lipid profile (total lipids, cholesterol, trigylcerides, HDL-Cholesterol and LDL-Cholesterol) and sex hormone profile (estradiol, progesterone, FSH, LH and prolactin) were estimated in' the sera of 25 postmenopausal breast cancer, before, 3 and 6 months after treatment with tamoxifen presenting to the outpatient clinics in National Cancer Institute (NCI) during the period of 1997-1998.
The study included to healthy age matched females as controls. Significant decreased mean values of total lipids, cholesterol and LDL-cholesterol at 3 and 6 months compared to their pretreatment values. On the other hand their were statistically significant increase in the concentration of triglycerides and HDL-cholesterol at 3 and 6 months after treatment compared to their pretreatment values. Similarly, it has been found also that there were statistically significant decrease in the concentration of estradiol, LH and prolactin at 6 months of receiving tamoxifen compared to their pretre-atment values. Also a comparative decrease in the concen-tration of both FSH and progesterone were detected in 3 and 6 months of treatment compared to their pretreatment mean values. A negatie correlation between the concentration of all studied parameters and the duration of treatment were detected except for triglyceride and HDL Cholesterol which revealed positive correlation with duration of treatment. There were a statistically significant elevation in the rate of decrease in total lipids, cholesterol, LDL-cbolesterol estradiol and prolactin among the first three months of treatment compared to the second three months. On the other hand there were statistically significant elevation in the rate of increase in the concentration triglycerides and HDL-Cholesterol in the first three months compared to the second three months. In case of progesterone, the rate of decrease was more in the second three months compared to the first three months and the difference was statistically significant.
The study included to healthy age matched females as controls. Significant decreased mean values of total lipids, cholesterol and LDL-cholesterol at 3 and 6 months compared to their pretreatment values. On the other hand their were statistically significant increase in the concentration of triglycerides and HDL-cholesterol at 3 and 6 months after treatment compared to their pretreatment values. Similarly, it has been found also that there were statistically significant decrease in the concentration of estradiol, LH and prolactin at 6 months of receiving tamoxifen compared to their pretre-atment values. Also a comparative decrease in the concen-tration of both FSH and progesterone were detected in 3 and 6 months of treatment compared to their pretreatment mean values. A negatie correlation between the concentration of all studied parameters and the duration of treatment were detected except for triglyceride and HDL Cholesterol which revealed positive correlation with duration of treatment. There were a statistically significant elevation in the rate of decrease in total lipids, cholesterol, LDL-cbolesterol estradiol and prolactin among the first three months of treatment compared to the second three months. On the other hand there were statistically significant elevation in the rate of increase in the concentration triglycerides and HDL-Cholesterol in the first three months compared to the second three months. In case of progesterone, the rate of decrease was more in the second three months compared to the first three months and the difference was statistically significant.
Other data
| Title | EFIFECT OF TAMOXIFEN ON SEX HORMONES AND LIPID PROFILES IN PATIENTS WITH BREAST CANCER | Other Titles | تأثير التامكسيفين على الهرمونات الأنثوية والدهون في مرضى سرطان الثدي | Authors | ADEL MOHAMED SHENDY | Issue Date | 2002 |
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