Effect of Metformin on SerumAdiponectin Level in Overweight Women with Polycystic Ovary Syndrome

Abstract

This case control study was conducted at the department of Obstetrics and Gynecology, Ain-shams university maternity hospital, during the period between March 2014 & December 2014. 60 selected women aged between 18 and 40 years were recruited from the outpatient clinic of infertility and divided into study group and control group. The study was approved from the ethical committee of the department of obstetrics and gynecology, faculty of medicine, Ain shams university. Informed written consent was taken from all participants before recruitment in the study and after explaining the purpose of the study. The study evaluated serum adiponectin concentrations in PCOS women before and after metformin and healthy control group. The Study group ofPCOS women presented significantly lower levels of adiponectin (5.93 ± 1.12 μg/ml) when compared with the control group (17.59 ± 4.44 μg/ml)(P<0.001), which suggests that decreased serum adiponectin may relate to the presence of PCOS this finding goes with Sieminska et al. (2004), Carmina et al. (2005), Ardawi and Rouzi (2005). The studies done by Orio et al. (2003), Panidis et al. (2003), Glucelik et al. (2006) and Spranger et al. (2004), were in contrast to the present study results.