Synthesis and Characterization of New Solid Complexes of Hydrazone Derivatives: Nano-particle Studies and Different Potential Applications

Abstract

New transition and lanthanide metal binary nano-complexes as well as dispersed into silica matrix were prepared in nano domain with crystalline or amorphous structures for biomedical applications. Also, the mixed ligand nano-complexes were prepared by using potassium thiocyanate (KSCN), 8-hydroxyquinoline (8-HOqu), 2,2/-bipyridyl (Bpy) and 1,10-phenanthroline (Phen) as secondary ligands. The antimicrobial and antioxidant activities for H2L1 Ligand and its binary nano-complexes were investigated. The H2L1 and its nano-complexes (1-32) were tested for their in vitro cytotoxicity against Ehrlich Ascites Carcinoma cell line (EAC). Sm(III) complex-silica xerogel nanohybrid have highest antitumor activity. The Sm(III) complex drug storage/release process was investigated by absorption spectra. The toxicity test on mice showed that Binary Cu(II), Zn(II) and Sm(III) nano-complexes as well as Sm(III) complex-silica xerogel nanohybrid have lower toxicity than standard cisplatin. Therapeutic effect of Sm(III) nano-complex dispersed in silica xerogel on tumor of colon (in vivo) was studied as antitumor drug on mice.