NEUTROPHIL PHAGOCYTIC FUNCTIONS AND SERUM OPSONiC ACTIVITY IN CHILDREN WITH NEPHROTIC SYNDROME
Safaa Omar Mahmoud Hassan;
Abstract
Children with NS are more vulnerable to infections which if not recognized early and treated promptly may prove fatal.
Various mechanisms have been suggested for the increased susceptibility to bacterial infections in nephrotic children. Hypogammaglobulinaemia is partly responsible. Defective humoral responses to bacteria, immunosuppressive therapy, the oedema fluid acting as a culture medium, protein deficiency and decreased perfusion of spleen due to hypovolaemia all those may be responsible factors. Another factor that could contribute to high rate of infections in the nephrotic subject, is a decreased serum level of alternate complement pathway factor B which is linked to defective opsonization of E coli in nephrotic children. Recently the presence of abnormalities in T-cell function in patient with NS was suggested. Some aspects of phagocytosis . were found to be impaired in children with NS as decreased opsomc and chemotactic activities and decreased myeloperxidase content of PMN Ieucocytes, which niay explain defective oxygen dependent killing by phagocytes. However data are incomplete.
Various mechanisms have been suggested for the increased susceptibility to bacterial infections in nephrotic children. Hypogammaglobulinaemia is partly responsible. Defective humoral responses to bacteria, immunosuppressive therapy, the oedema fluid acting as a culture medium, protein deficiency and decreased perfusion of spleen due to hypovolaemia all those may be responsible factors. Another factor that could contribute to high rate of infections in the nephrotic subject, is a decreased serum level of alternate complement pathway factor B which is linked to defective opsonization of E coli in nephrotic children. Recently the presence of abnormalities in T-cell function in patient with NS was suggested. Some aspects of phagocytosis . were found to be impaired in children with NS as decreased opsomc and chemotactic activities and decreased myeloperxidase content of PMN Ieucocytes, which niay explain defective oxygen dependent killing by phagocytes. However data are incomplete.
Other data
| Title | NEUTROPHIL PHAGOCYTIC FUNCTIONS AND SERUM OPSONiC ACTIVITY IN CHILDREN WITH NEPHROTIC SYNDROME | Other Titles | الوظائف البلعمية للخلايا البيضاء المتعادلة والنشاط الطهوى للمصل فى الاطفال المصابين بالتناظر النفروزى (المتلازمة الكلوية) | Authors | Safaa Omar Mahmoud Hassan | Issue Date | 2003 |
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