HEPATITIS DELTA VIRUS AND DECOMPENSATED LIVER DISEASE WITH AND WITHOUT SCHISTOSOMIASIS: THE IMPACT OF HDV ON THE HEPATORENAL SYNDROME

Abstract

The ann of this work is to detect the role played by HDV in the fulminant hepatitis and to estimate the effect of this virus on the progression and the severity of the chronic hepatitis including one of its tenninal outcomes: the hepatorenal syndrome.

ln this work, 70 patients were studied clinically, biochemically, parasitologically, serologically and histopatholo­ gically.

The first group included 20 patients with fulminant hepatic failure. They were admitted to Embaba Fever Hospital. The serological examination of these patients revealed that HDV was responsible for the fulminant hepatitis in 7 patients (35%). One of them had HBV/HDV coninfection. This patient survived more than two weeks despite the encephalopathy and the poor clinical condition in the first week. The other six patients had HDV as a superinfection. These 6 patients were dead by the end of the second week of admission. The etiology of the non-delta patients was as follows: 3 patients had acute fulminant A hepatitis (15%), 6 patients had pure HBV fulminant hepatitis (30%), 2 patients had HEY infection (10%) and 1 patient was infected by HCV (5%). On case remained undiagnosed (5%).