Serum amyloid A level in women with primary un explained early recurrent pregnancy loss

Abstract

Recurrent pregnancy loss (RPL) is defined by the American society for reproductive medicine as the presence of two or more failed pregnancies, proved either by sonographic examination or histopathology. RPL may be either a primary or secondary process: primary , RPL refers to those women with RPL who never had a live birth before,where as secondary RPL is occurrence of two or more consecutive spontaneous miscarriage after previous viable pregnancy. Serum amyloid A (SAA) is a family of closely related apo-lipoproteins associated with high density lipoprotein (HDL). Subclasses of SAA isoforms are differentially expressed constitutively and during inflammation. In addition to maternal blood were collected, SAA and CRP reached the maximum maternal serum levels 24 hours after delivery, while cytokines remained constant over time. Currently, no information is available on maternal SAA levels in early pregnancy loss. The purpose of this study was to evaluate maternal circulating SAA level in women with RPL by comparing them with healthy control. In this present study of serum amyloid A level the first important finding showed a highly significant increase(p-value<0.001) in patients with recurrent pregnancy loss collectively when compared with healthy control group. It is not clear whether elevated SAA level is the direct cause for pregnancy failure or just a marker of underling dysfunction in the innate immune system that causes abnormal production of cytokines or growth factors that over-induce SAA synthesis. Second important finding was serum amyloid A had an excellent discrimin