Synthesis and characteristic studies of metal complexes of some Schiff bases derived from o-acetoacetylphenol
Mohammed Ali Naji Hassan Mahdi;
Abstract
Abstract
New three Schiff base ligands, (H3L1, H3L2, H3L3) resulting from condensation of o-acetoacetylphenol with salicylaldehyde hydrazone , 2-hydroxybenzohydrazide and benzoylhydrazide, respectively were synthesized. Reactions of the ligands with alkaline earth metals such as: magnesium(II), calcium(II), strontium(II) and barium(II) in the presence of LiOH; and some transition metal ions such as chromium(III), manganese(II), iron(III), cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and dioxouranium(VI) ions yielded mono-, bi- and trinuclear complexes. The complexes were characterized by elemental, thermal analyses, IR, electronic, 1H NMR, ESR and mass spectra as well as conductivity and magnetic susceptibility measurements. Different geometrical structures were proposed for the metal complexes of the Schiff base ligands. Molecular orbital calculations were carried out on the free ligands and their complexes using HyperChem 7.5 program at semiempirical PM3 level. The calculated structural parameters data are found to be linearly correlated with some of the experimental data such as: TGA, IR frequencies and biological activity results. The Schiff base ligands and some of their complexes showed antibacterial activity towards some of Gram–positive, Gram–negative bacteria, yeast (C. albicans) and fungus (A. fumigatus). The antitumor activity of the ligands H3L1 and H3L2 and their Ni(II) and Cu(II) complexes was investigated against HepG2 cell line.
New three Schiff base ligands, (H3L1, H3L2, H3L3) resulting from condensation of o-acetoacetylphenol with salicylaldehyde hydrazone , 2-hydroxybenzohydrazide and benzoylhydrazide, respectively were synthesized. Reactions of the ligands with alkaline earth metals such as: magnesium(II), calcium(II), strontium(II) and barium(II) in the presence of LiOH; and some transition metal ions such as chromium(III), manganese(II), iron(III), cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and dioxouranium(VI) ions yielded mono-, bi- and trinuclear complexes. The complexes were characterized by elemental, thermal analyses, IR, electronic, 1H NMR, ESR and mass spectra as well as conductivity and magnetic susceptibility measurements. Different geometrical structures were proposed for the metal complexes of the Schiff base ligands. Molecular orbital calculations were carried out on the free ligands and their complexes using HyperChem 7.5 program at semiempirical PM3 level. The calculated structural parameters data are found to be linearly correlated with some of the experimental data such as: TGA, IR frequencies and biological activity results. The Schiff base ligands and some of their complexes showed antibacterial activity towards some of Gram–positive, Gram–negative bacteria, yeast (C. albicans) and fungus (A. fumigatus). The antitumor activity of the ligands H3L1 and H3L2 and their Ni(II) and Cu(II) complexes was investigated against HepG2 cell line.
Other data
| Title | Synthesis and characteristic studies of metal complexes of some Schiff bases derived from o-acetoacetylphenol | Other Titles | تحضير ودراسة المتراكبات الفلزية لبعض قواعد شيف المشتقة من اورثو أسيتو أسيتيل فينول | Authors | Mohammed Ali Naji Hassan Mahdi | Issue Date | 2017 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.