ROLE OF SURGERY, CHEMOTHERAPY AND RADIOTHERAPY IN TREATMENT OF 4 LOCALLY ADVANCED NON SMALL CELL LUNG CANCER

Abstract

This study included fourty previously tmtreated patients with locally advanced (stage IliA or IIIB) and histologically proven NSCLC , presented at Clinical Oncology Department , Tanta University Hospital during the period from July 2001 to Jtme 2005 .

The aim of this work was , assessment of two chemotherapy regimens ; gemcitabine I cisplatin versus etoposide I cisplatin , evaluation the possibility of surgery after induction chemotherapy treatment and evaluation the role of adjuvant radiotherapy in the treatment oflocally advanced NSCLC .

All patients were randomized into two tratment (GIC and EIC) anus , each ann included 20 patients . The patients in GIC ann were treated with 1.250 gmlm2 gemcitabine i.v infusion given on days 1 and 8 , and 100 mg/m2 cisplatin

i.v infusion given on day 1 , while the patients in EIC arm were treated with100 mg!mi i.v etoposide given on day 1 to 3 and 100 ;ng/m2 i.v infusion cisplatin given on day 1 in every 21 day cycle . The two studied chemotherapy regimens was given as induction treatment for 3 cycles and according to the treatment response all patients were evaluated for the possibility of radical surgical resection plus radiation therapy 60 Gy I 30 fractions I 6 weeks or to continue their treatment with the same chemotherapy regimen (maximum six cycles) .

The age of patients was ranged from 31 to 77 years and the mean age was•

56.2 ± 11.78 years . The male to female ratio was 2.6 : 1 . Sixty percent of patients were heavy smokers with a mean munber of 20 cigarettes per day and a• duration of smoking ranged from 10 to 40 years .