Assessment of Vitamin D Status among Prediabetic Patients

Abstract

Per-diabetes is a substantial risk factor for progression of diabetes and diagnosed by (IGT and ∕ or IFG). Microvascular complications, including retinopathy, chronic kidney disease, and neuropathy, and cardiovascular disease have been associated with prediabetes (Plantinga et al., 2010). Vitamin D plays a pivotal role in calcium metabolism and vitamin D deficiency may be associated with a range of serious diseases including cancer, cardiovascular disease, and type 2 diabetes (Shapses, 2012). Recently, some studies have shown that the prevalence of vitamin D deficiency has increased and more than 50% of adult age suffer from this deficiency (Sahyoun, 2002). This study aimed at evaluating vitamin D status in pre-diabetic in cases with impaired glucose tolerance and impaired fasting glucose. This is a Cross sectional study that was conducted on 80 cases that included and divided into four groups. Prediabetic group of 40 consecutive patients (with IFG and IGT), 20 cases type 2 DM and the healthy group of 20 control cases. Comparing the vitamin D level of the four groups revealed that, there was statistically significant difference among studied groups as regards the vitamin D level that was lowest in diabetic cases than cases of IFG, IGT compared to healthy control cases (p=0.001). There was significant -ve correlation between vitamin D and BMI in group 2 (IFG) (r= -0.461 and p=0.041), systolic blood pressure among cases with IGT (r= -0.577 and p=0.008), and Albumin among group 2 (IFG) (r= -0.606 and p= 0.005). There was also statistically significant +ve correlation between vitamin D and FBG in control group (r= 0.483 and p= 0.031). There was a statistically significant difference among the groups as regards the BMI, systolic and diastolic BP, mean fasting blood glucose and HOMA (P< 0.01). Whereas the difference was statistically insignificant among the groups as regard the age (p>0.05), gender (P value=0.943) and Mean Fasting insulin (P =0.846).