Labetalol Versus Alpha Methyldopa for Control of Pregnancy Induced Hypertention RANDOMIZED CONTROLLED TRIAL

Abstract

Background: Pregnancy-induced hypertension is associated with various adverse fetal and maternal outcomes. The use of anti-hypertensive drugs in pregnancy is controversial. We conducted a prospective study to evaluate the comparative effectiveness and safety of methyldopa and labetalol monotherapy in patients with pregnancy-induced hypertension. Objective: To compare the efficacy & safety of Methyldopa and Labetalol on Blood pressure in Pregnancy-induced hypertension (PIH) patients. Methods: Patients n= 88 pregnant women with blood pressure of 140/90 mm Hg or more with ≥1+ proteinuria and gestational age between 22-40 weeks were included in this randomized controlled trial study. Cases were randomly divided into two groups of 44 each. Group –I received labetalol (n=44) and Group II received methyldopa (n=44). Blood pressure was measured at 48 h of initiation of antihypertensive drugs. Patients were also followed up for