CLINICAL EVALUATION OF CIS-ATRACURIUM BESYLATE IN CHRONIC LIVER DISESES - A COMPARATIVE STUDY WITH ATRACURIUM
Sameh Fouad Abdel-Aziz;
Abstract
Background
The liver is the main organ responsible for the metabolism of drugs. In chronic liver diseases, handling of drugs by the liver may be disturbed greatly by several mechanisms, including principally, altered absorption, distribution and disposition (elimination).
Hepatic elimination of drugs is dependent on three factors:
1- Hepatic blood perfusion.
2- Extraction of the drug (extraction ratio) by the liver from the blood i.e. metabolism and excretion.
3- Binding ofthe drug to proteins.
Changes in these factors will alter the pharmacokinetic behaviour of the drug, and hence its pharmacodynamics.
Other mechanisms of altered pharmacokinetics include changes in the protein binding of drugs and changes in volume of distribution. In patients with chronic liver diseases, while plasma albumin concentration is usually reduced, globulin fractions may be increased.
The liver is the main organ responsible for the metabolism of drugs. In chronic liver diseases, handling of drugs by the liver may be disturbed greatly by several mechanisms, including principally, altered absorption, distribution and disposition (elimination).
Hepatic elimination of drugs is dependent on three factors:
1- Hepatic blood perfusion.
2- Extraction of the drug (extraction ratio) by the liver from the blood i.e. metabolism and excretion.
3- Binding ofthe drug to proteins.
Changes in these factors will alter the pharmacokinetic behaviour of the drug, and hence its pharmacodynamics.
Other mechanisms of altered pharmacokinetics include changes in the protein binding of drugs and changes in volume of distribution. In patients with chronic liver diseases, while plasma albumin concentration is usually reduced, globulin fractions may be increased.
Other data
| Title | CLINICAL EVALUATION OF CIS-ATRACURIUM BESYLATE IN CHRONIC LIVER DISESES - A COMPARATIVE STUDY WITH ATRACURIUM | Other Titles | دراسة اكلينيكية لعقار سيس اتراكيوريوم فى حالات امراض الكبد المزمنة بالمقارنة مع عقار الأتراكيوريوم | Authors | Sameh Fouad Abdel-Aziz | Issue Date | 1999 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.