Clinicopathological Features and Survival Outcomes of Colorectal Cancer in Young versus Elderly Egyptian Patients

Abstract

he purpose of the current study is to compare the clinical features, histopathologic characteristics and survival outcomes in young patients with those in the older age group in Egyptian patients, and to assess the role of p53 expression in prognosis with histopathological characteristics and other clinical variants of CRC tumor. The present study deals with 137 cases of CRC taken from histopathological reports. They were 53 cases ≤ 40 years old (38.7%), and 84 cases > 40 years old (61.3%), ages ranged from 23 years to 78 years with mean age 47.3 ± 14.4 years. they were 55 males (40.1%), and 82 females (59.9%) (M: F = 0.6:1). Out of the 137 cases, 56 cases that had histological slides and blocks were examined histologically to confirm malignancy, and their characteristics. These cases were stained with p53 later on, they were 32 cases positive p53 expression (57.1%) and 24 cases negative p53 expression (42.9%). they were 24 cases ≤ 40 years (42.9%) and 32 cases > 40 years (57.1%), their age ranged from 24 years to 76 years with mean age 47.3 ± 13.7 years. The results of the present study is divided into two main categories: The first one, statistical correlations between age with other variables, in which there were statistically significant