Histological Analysis of Bone Healing After Socket Augmentation Using Platelet-Rich Fibrin Versus Xenogeneic Bone Graft

Abstract

The current study was conducted to evaluate the efficacy of the platelets rich fibrin as a grafting material in post extraction socket in the anterior maxillary region to reduce bone loss versus Bio-Oss® Xenograft using histological analysis. Forty two fresh extraction sockets in twenty seven patients with average age of 35.5±5 years old. The patients were randomally allocated into three main groups. The study group consisted of sockets where PRF was placed, the positive control group consisted of sockets where bio-oss® xenogenic bone graft were placed along with collagen plug and the negative control group consisted of sockets that were left to heal without the use of any grafting materials. Each group was further sub-divided into two subgroups: core biopsy harvested and implants placed at three months, and at six months. All samples were assessed histologically and histomorphometrically. Results were tabulated and assessed using Multivariant ANOVA test to assess effect of time and socket augmentation material on quantity and quality of newly formed bone. Histologic and histomorphometric assessment using H&E and MT showed that, the percentage of newly formed bone after tooth extraction