The Effects of Airway Pressure Release Ventilation on Blood pressure and Urine Output in Neonate with Respiratory Distress (RD)

Abstract

It has been known that mechanical ventilation can induced changes in renal function. These changes are secondary to: 1-Renal responses to hemodynamic changes resulting from high intrathoracic pressure. 2- Humoral responses, including antidiuretic hormone (ADH), atrial natriuretic peptide (ANP), and renin-angiotensin aldosterone changes occurring with ventilation. Hence the aim of this work to study the effect of airway pressure release ventilation on blood pressure and urine output in neonates with respiratory distress for this purpose 100 neonates (50 fullterms and 50 preterms) were recruited from neonatology unit, Gynecology and Obstetrics Hospital at Ain Shams University Hospital included in the study. All neonates subjected to the following: 1. Careful history taking including: -Antenatal history • Maternal history (DM, pre-eclampsia, drugs, SLE) • Maternal infection (TORCH infection) • Maternal bleeding. • Prolonged rupture of membranes >18 hours.