Physiological and Molecular Studies on Apoptosis in Leukemia

Abstract

transformation occurs at early stages in the development of the affected blood cell. If untreated, these diseases can be rapidly fatal. The goal of this project was to study the anti-tumor effect of chemotherapy drugs Cytarabine (Ara-C) plus to Daunorubicin and vincristine plus to dexamethasone as inhibitors of leukemic cells expressing the oncogene, which causes AL. The drugs were also tested in vivo establishing their toxicity in AL patients that induced apoptosis, and determining their efficacy in a leukemia. The acute leukemia treatment strategies with chemotherapy drugs (D4 and D14). However, our research shows that two important factors in decreasing the toxicity and increasing the efficacy of AL treatment (apoptosis) are the amount of the concentration of drug dose. These therapeutic techniques may be used to expand our treatment options for AL. AML cases show no response to the treatment, while; ALL show a good response and easily recovered.