Effects of Ivermectin and Doramectin Drugs in Concurrent with Vitamin E on the Fertility in Male Rats

Abstract

The present study was designed to assess the protective and antioxidant effects of ivermectin (IVM) and doramectin (DOM), at therapeutic and double therapeutic dose, when orally given alone and in combination with vitamin E against sodium valproate (SVP)-induced testicular toxicity and oxidative stress in male rats. In addition, effects of both drugs alone and in combination with vitamin E on liver and kidney functions, lipid peroxidation, blood picture and histopathology of testis, liver and kidneys were also studied. A total of 70 Sprague-Dawley sexually mature male rats were randomized into 2 main groups, of 35 rats each. Each main group was subdivided into equal 7 subgroups. For studying effects of ivermectin (IVM) and vitamin E (Vit. E.), subgroup (1) was used as a negative control. The remaining 6 subgroups were intoxicated by oral single dose of sodium valproate (SVP) during the last week of experiment (65 days) to induce testicular damage. Subgroup (2) was kept as a positive control (intoxicated rats), while subgroups (3), (4), (5), (6) and (7) were respectively pretreated with therapeutic dose (0.2 mg/kg) of IVM alone, double therapeutic dose (0.4 mg/kg b.wt.) of IVM alone, vitamin E (40 mg/kg b.wt.) alone, therapeutic dose of IVM concomitantly with Vit. E and double therapeutic dose of IVM concomitantly with Vit. E. - 151 - For