The Effect of Pregabalin Versus Carbamazepine on the Gingiva of Albino Rats with the Possible Modulatory Action of Acasia Arabica

Abstract

Epilepsy is a common chronic neurological disorder in humans. It is a condition in which the patient has recurrent seizures. Epilepsy is treated by a group of drugs called anti-epileptic drugs (French, 1994). All antiepileptic drugs have a relatively high incidence of adverse reactions. Gingival enlargement is one of the most frequent and troublesome adverse effects associated with the administration of phenytoin, and carbamazepine (Perucca, 2005). In fall 2005, Pfizer released pregabalin (Lyrica) as adjunct therapy in the treatment of epilepsy. PGB is generally well tolerated and adverse effects in patients on pregabalin treatment were mild-to-moderate (Rosenstock et al., 2004). Aim of the Study: The aim of this study is comparing the effect of anticonvulsant Pregabalin versus Carbamazepine on the gingiva of Albino rats and evaluation of modulative effect of Acasia arabica in association with them.