Microalbmninuria As As Early Marker Of Osteopesia In Nos Insulin Dependent Diabetic Patients

Abstract

Diabetic osteopenia has been known as one of the chronic complications of type I diabetes mellitus but is controversed in type II. Microalbuminuria is highly predictive of the development of diabetic nephropathy and other vascular complications. A trial was done to assess bone mineral density (BMD) in type II diabetes mellitus and to find any possible relation between microalbuminuria and BMD. So, Sixty four non-insulin dependent diabetic patients, twenty three males and forty one females (Twenty three <45 years old, eighteen >45 years old), and eighteen healthy control, matched for age, gender and weight, were selected from Kasr El Aini Hospital and their BMD was studied by CT densitometry of their lumbar vertebrae. Microalbuminuria was detected by immunonephlometry.

All diabetic patients were found to have decreased BMD as compared to control group (147.89 ±. 35.15 gm/cm3 Vs 186.83 ± 33.30 gm/cm3, P = < .0005) irrespective to gender (150.34 ± 32.69 gm/cm3 Vs 190.17 ±4.49

gm/cm3, P = <.0005 for males and 146.51 ± 36.78 gm/cm3 Vs 185.17 ± 41.18 gm/cm3 , P = < .003 for females) or age (156.71 ± 35.51 gm/cm3 Vs 195.40 ± 10.83 gm/cm3, P = < .0005 in females< 45 years and 133.48 ± 35.09 gm/cm3

Vs 174.93 ± 57.98 gm/cm3, P = <.045 in females> 45 years old)