Vitamin A Status in Children with Chronic Liver Diseases
Samia Elmohamedy Hussein;
Abstract
Chronic liver diseases in children are relatively common disorders with minimal symptoms but long-term risk of significant morbidity and mortality particularly in developing countries. They are defined by continuity of clinical or biochemical evidence of hepatic dysfunction for longer than 6 months.
Vitamin A is the name of a group of fat-soluble retinoids, including retinol, retinal, retinoic acid, and retinylesters.
Malabsorption of dietary fat and fat-soluble vitamins including vitamin A is one of the major complications of childhood cholestatic liver disorders, vitamin A absorption depends on concentration of intraluminal bile acids adequate for micellar solubilisation. Therefore, the reduced biliary secretion of bile acids during cholestasis causes vitamin A malabsorption and potential deficiency of vitamin A.
The aim of our work was to measure the serum level of vitamin A in children with chronic liver diseases (CLDs) and correlate them with the severity of liver dysfunction in the Hepatology Clinic in Children's Hospital– Ain Shams University.
This is case control study included:
Patients: sixty patients of children and adolescents following up at the Pediatric Hepatology Clinic at Faculty of Medicine Ain Shams University in the period from March 2012 to November 2012. They comprised 25(41.7%) females and 35(58.3%) males, their ages ranged from 5 to 18 years with mean of age and ± SD (10.9 ±3.8).
Controls: Thirty healthy child attending out patients clinic, at Faculity of Medicine Ain Shames University. They comprised 13(43.3%) females and 17(56.7%) males, their ages ranged from 5 to 17years with a mean of age ± SD (10.8 ±3.9).
- All patients were subjected to the following:
1. Personal history: age, sex, residence and social class.
2. Medical history suggestive of chronic liver diseases.
3. Clinical examination.
a) General examination; with special emphasis on jaundice, pallor, cyanosis.
b) Abdominal examination; with special emphasis on liver size, consistency, surface and edges; spleen size.
c) Eye examination an ocular examination will be performed by a paediatric ophthalmologists, including direct assessment of the cornea and conjunctiva by slit-lamp,
Vitamin A is the name of a group of fat-soluble retinoids, including retinol, retinal, retinoic acid, and retinylesters.
Malabsorption of dietary fat and fat-soluble vitamins including vitamin A is one of the major complications of childhood cholestatic liver disorders, vitamin A absorption depends on concentration of intraluminal bile acids adequate for micellar solubilisation. Therefore, the reduced biliary secretion of bile acids during cholestasis causes vitamin A malabsorption and potential deficiency of vitamin A.
The aim of our work was to measure the serum level of vitamin A in children with chronic liver diseases (CLDs) and correlate them with the severity of liver dysfunction in the Hepatology Clinic in Children's Hospital– Ain Shams University.
This is case control study included:
Patients: sixty patients of children and adolescents following up at the Pediatric Hepatology Clinic at Faculty of Medicine Ain Shams University in the period from March 2012 to November 2012. They comprised 25(41.7%) females and 35(58.3%) males, their ages ranged from 5 to 18 years with mean of age and ± SD (10.9 ±3.8).
Controls: Thirty healthy child attending out patients clinic, at Faculity of Medicine Ain Shames University. They comprised 13(43.3%) females and 17(56.7%) males, their ages ranged from 5 to 17years with a mean of age ± SD (10.8 ±3.9).
- All patients were subjected to the following:
1. Personal history: age, sex, residence and social class.
2. Medical history suggestive of chronic liver diseases.
3. Clinical examination.
a) General examination; with special emphasis on jaundice, pallor, cyanosis.
b) Abdominal examination; with special emphasis on liver size, consistency, surface and edges; spleen size.
c) Eye examination an ocular examination will be performed by a paediatric ophthalmologists, including direct assessment of the cornea and conjunctiva by slit-lamp,
Other data
| Title | Vitamin A Status in Children with Chronic Liver Diseases | Other Titles | قياس فيتامين )أ( لدى الأطفال المصابون بأمراض الكبد المزمنة | Authors | Samia Elmohamedy Hussein | Issue Date | 2014 |
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