Anti-hyperlipidemic and Anti-hypercholesterolemic effect of aqueous extract of guava (Psidum guajava Linn.) leaves on rats

Abstract

The aim of the present study is to investigate the ameliorative effect of aqueous guava leaves extract(AGLE) with different doses (200, 350, 500 & 650 mg/kg b.wt.) taken p.o in rats fed high fat high cholesterol (HFHC) diet for 8 weeks. The four doses of AGLE cause a significant decrease in food intake, final body weight, body weight gain, serum TAGs, VLDL-C, risk ratio as well as liver TAGs and malondialdehyde level. Also doses of AGLE (350, 500 and 650 mg/kg b.wt.) cause a significant decrease in relative liver weight, serum AST and LDL-C, but it was found a significant increase in HDL-C and leptin hormone. While the doses (500 & 650 mg/kg b.wt.) cause a significant decrease in serum TC. The highest dose causes a significant decrease in serum ALT and adiponectin hormone. Total liver cholesterol was decreased significantly in groups given (200&350 mg/kg b.wt.) but no significant decrease in doses (500 & 650 mg/kg b.wt.). No change in ghrelin hormone in the four treated groups fed HFHC diet and given AGLE compared to positive control.