Serum Insulin-Like Growth Factor-1 and Insulin Like Growth Factor Binding Protien-3 in Relation to Echocardiography Findings in Infants of Diabetic Mothers and Macrosomic Neonates

Abstract

acrosomia is an important clinical problem in infants of diabetic mothers and the precise mechanisms for the development of macrosomia remain unclear. Insulin like growth factor-1 and insulin like growth factor binding protein-3 could influence fetal growth and visceral hypertrophy including hypertrophic cardiomyopathy. Infants with macrosomia have an increased chance of having cardiac problems. Hypertrophic cardiomyopathy with or without obstruction of the left ventricular outflow tract occurs in 10% to 20% of the macrosomic neonates. The aim of this study was: 1) To assess serum level of IGF-1 and IGF binding protein-3 in infant of diabetic mothers and macrosomic infants of non-diabetic mothers. 2) To evaluate whether there was an association between morphological heart parameters and cardiac functions estimated during echocardiographic examination in infants of diabetic mothers and macrosomic neonates and serum level of IGF-1 and IGF binding protein-3 concentration at birth.