Vitamin C versus oral metronidazole in cases with bacterial vaginosis: Randomized Clinical trial

Abstract

acterial vaginosis is the commonest cause of vaginal discharge occurring in women attending gynecological clinics in our country. BV represents a unique upheaval of the complex vaginal bacterial flora with the disappearance of Lactobacilli and its replacement by a mixed flora of aerobic, anaerobic and microaerophilic species. Normally, lactic acid, hydrogen peroxide, and bacitracin are produced by Lactobacillus and help the vagina to keep its acidic PH and thus protect against infections caused by microorganisms. This study aim to compare between the efficacy of vaginal vitamin C and oral metronidazole in treatment of BV. This randomized clinical trial was carried out at Ain Shams Maternity Hospital out-patient clinic, in the period from August 2016 to February 2017. The study included one hundred non-pregnant women who had BV diagnosed clinically by Amsel criteria (white grayish discharge, PH>4.5, Wiff test, clue cells in wet smear) and laboratory (Gram stain with objective scoring system) Nugent criteria. Patients enrolled in the study were randomly assigned into two groups: