MODULATION OF IN-VITRO COLONY FORMATION OF PHILADELPHIA POSITIVE CELLS BY ANTISENSE OLIGODEOXYNUCLEOTIDES IN CML
Samah M. Abd EL Hameed;
Abstract
CML is a prototype of a disease in which the molecular oncogenesis is known, . caused by the Philadelphia chromosome. The introduction of antisense oligodeoxynucleotides (AS-ODNs) against the transcribted mRNA of b3a2 and b2a2 breakpoints leads to suppresion of translation of the abnormal p210 tyrosine kinase protein. Comparing b2a2 AS-ODNs inhibition ratio to both b3a2 and TAT AS-ODNs inhibition ratios showed a highly significant statistical difference. Also there was a significant
•negative statistical correlation between AS-ODNs inhibition
ratios• and both basophil percent and LAP score in chronic phase CML thus AS-ODNs can be used to purge autologous stem cells to reduce malignant cells before its transplantation in chronic phase CML.
•negative statistical correlation between AS-ODNs inhibition
ratios• and both basophil percent and LAP score in chronic phase CML thus AS-ODNs can be used to purge autologous stem cells to reduce malignant cells before its transplantation in chronic phase CML.
Other data
| Title | MODULATION OF IN-VITRO COLONY FORMATION OF PHILADELPHIA POSITIVE CELLS BY ANTISENSE OLIGODEOXYNUCLEOTIDES IN CML | Other Titles | دراسة تأثير سلسلة الوحدات العاكسة لشفرة الحامض النووى على المستعمرات المكونة من الخلايا الإيجابية لفيلاديلفيا كروموزوم فى سرطان الدم الميلويدى | Authors | Samah M. Abd EL Hameed | Issue Date | 2001 |
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