Effect of AT1-receptor Blockers on Cardiac Remodeling Following acute myocardial infarction Role of AT1-receptor Gene Polymorphism
Maha Mohamed Saber Khalil;
Abstract
Phannacogenomics aims at understanding how genetic variation contributes to variations in response to drugs. The variations that exist even in the untranslated regions of the genes encoding drug receptors can account for the variable response detected in different patients receiving the same drug.
)> This study is an attempt to assess the possible effect of angiotensin II type-!receptor gene polymorphism (A 1166C) on patient response to angiotensin II type-!receptor blocker (losartan), as regards cardiac remodeling after acute myocardial infarction.
)> To achieve this goal, we studied 33 patients with acute anterior myocardial infarction (mean age: 55.2 ).
)> For each patient DNA was extracted from a peripheral blood sample. AT1 receptor gene was amplified by PCR-technique (30
cycles). Then, AT1 receptor gene polymorphism (A 1166C) was
determined using a restrictive endonuclease (D de I). Thirteen
patients were A/C and 20 were A/A.
)> There was no statistically significant association between the AT1 receptor genotype and the baseline echocardiographic parameters (all p-values > 0.05), indicating that this polymorphism is rather implicated in the variation of response to both receptor agonists and antagonists than being a marker of CAD.
)> With the AT 1-receptor blocker, losartan, there was a significant improvement of the fractional shortening and a significant reduction of the score of regional wall motion abnormalities in
patients with the C allele. This is in contrast to patients treated with
ACE inhibitor, captopril, where the changes in echocardiographic
parameters were not statistically significant when compared in patients with either genotype.
)> This study is an attempt to assess the possible effect of angiotensin II type-!receptor gene polymorphism (A 1166C) on patient response to angiotensin II type-!receptor blocker (losartan), as regards cardiac remodeling after acute myocardial infarction.
)> To achieve this goal, we studied 33 patients with acute anterior myocardial infarction (mean age: 55.2 ).
)> For each patient DNA was extracted from a peripheral blood sample. AT1 receptor gene was amplified by PCR-technique (30
cycles). Then, AT1 receptor gene polymorphism (A 1166C) was
determined using a restrictive endonuclease (D de I). Thirteen
patients were A/C and 20 were A/A.
)> There was no statistically significant association between the AT1 receptor genotype and the baseline echocardiographic parameters (all p-values > 0.05), indicating that this polymorphism is rather implicated in the variation of response to both receptor agonists and antagonists than being a marker of CAD.
)> With the AT 1-receptor blocker, losartan, there was a significant improvement of the fractional shortening and a significant reduction of the score of regional wall motion abnormalities in
patients with the C allele. This is in contrast to patients treated with
ACE inhibitor, captopril, where the changes in echocardiographic
parameters were not statistically significant when compared in patients with either genotype.
Other data
| Title | Effect of AT1-receptor Blockers on Cardiac Remodeling Following acute myocardial infarction Role of AT1-receptor Gene Polymorphism | Other Titles | تأثير مغلفات مستقبل الأنجيوتتسين 2- أ على إعادة تشكيل عضلة القلب بعد الاحتشاء الحاد دور الاختلاف الجينى لهذه المستقبلات | Authors | Maha Mohamed Saber Khalil | Issue Date | 2001 |
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