EVALUATION OF ANTIDIABETIC EFFECT OF BERBERINE IN TYPE 2 DIABETIC RATS MODELS
Marwa Mohamed Abd Elrahman;
Abstract
SUMMARY
Diabetes is attaining an epidemic stature throughout the world and the scenario in developing nations is worsening day by day. Type 2 diabetes mellitus (T2DM) is the most prevalent form, responsible for 90% of the disease prevalence. The progression of T2DM includes the development of insulin resistance, impaired glucose tolerance and eventual pancreatic β-cell dysfunction. The resulting chronic hyperglycemic condition in diabetes is associated with long term damage, dysfunction, and failure of various organs, such as eyes, kidneys, nerves, heart, and blood vessels.
Berberine is a medically important isoquinoline alkaloid, which exists in a number of medicinal plants and displays a broad array of pharmacological effects. This natural compound has been increasingly studied for its benefits against various metabolic diseases including diabetes.
The rats were allocated into two dietary regimens by feeding either normal diet or high fat diet (HFD) (58% fat, 25% protein and 17% carbohydrate, as a percentage of total kcal) ad libitum, respectively, for the initial period of 4 weeks.
After the 4 weeks of dietary manipulation, the group of rats fed by HFD were injected intraperitoneally (i.p.) with low dose of STZ (sigma) (35 mg/kg), while the respective control rats were given vehicle citrate buffer (pH 4.5) in a dose volume of 1 ml/kg, i.p. Seven days after streptozotocin injection, rats were screened for blood
Diabetes is attaining an epidemic stature throughout the world and the scenario in developing nations is worsening day by day. Type 2 diabetes mellitus (T2DM) is the most prevalent form, responsible for 90% of the disease prevalence. The progression of T2DM includes the development of insulin resistance, impaired glucose tolerance and eventual pancreatic β-cell dysfunction. The resulting chronic hyperglycemic condition in diabetes is associated with long term damage, dysfunction, and failure of various organs, such as eyes, kidneys, nerves, heart, and blood vessels.
Berberine is a medically important isoquinoline alkaloid, which exists in a number of medicinal plants and displays a broad array of pharmacological effects. This natural compound has been increasingly studied for its benefits against various metabolic diseases including diabetes.
The rats were allocated into two dietary regimens by feeding either normal diet or high fat diet (HFD) (58% fat, 25% protein and 17% carbohydrate, as a percentage of total kcal) ad libitum, respectively, for the initial period of 4 weeks.
After the 4 weeks of dietary manipulation, the group of rats fed by HFD were injected intraperitoneally (i.p.) with low dose of STZ (sigma) (35 mg/kg), while the respective control rats were given vehicle citrate buffer (pH 4.5) in a dose volume of 1 ml/kg, i.p. Seven days after streptozotocin injection, rats were screened for blood
Other data
| Title | EVALUATION OF ANTIDIABETIC EFFECT OF BERBERINE IN TYPE 2 DIABETIC RATS MODELS | Authors | Marwa Mohamed Abd Elrahman | Issue Date | 2016 |
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