Magnesium Sulphate for Fetal Neuroprotection in Patients Presenting by Intrapartum Fetal Distress at Term A Randomized Controlled Trial

Abstract

MgSO4 is known to be neuroprotective in preterm (Simhan et al., 2017), although the exact mechanisms of neuroprotection are unknown. However, controversy regarding its efficacy in protecting the brain in term infants who may suffer encephalopathy exists (Tagin et al., 2013). These thoughts emerged due to the fact that the outcomes of previous studies are highly inconsistent when it comes to neuroprotection. Differences in dose and timing of administration were present amidst evidence of beneficial effects (Galinsky et al., 2014: Brandon et al., 2015: Tagin et al., 2017). MgSo4 protect the fetal from in-utero hypoxia by preventing large blood pressure fluctuations, increase cerebral blow flow and decrease pro-inflammatory cytokines. MgSO4 also blocks excess release of glutamate in the calcium channel, protecting the susceptible fetal and newborn brains from glutamate-induced damage and antioxidant effects (Doyle, 2010). This study aim to determine the potential efficacy of magnesium sulphate as a neuroprotective agent for the