The Clinical Use of Cytogentics in Hematological Malignancies and Related Disorders
Hesham Kamal Habeeb;
Abstract
Hematological neoplasms are heterogenous group of diseases with diverse morphological , immunophenotypic and clinical characteristics
The cytogenetic abnormalities can be characterized as changes involving chromosome number or chromosome structure.
M onosomy 7 and trisomy 8 are two of the most common numerical a bnormalities in hematological neoplasia.
The study aimed at studying the lineage involved by the monosomy 7
and the trisomy 8
The work was performed on 10 patients at diagnosis before initiating therapy : 4 patients with non-Hodgkin's lymphoma
1 patient with solitary bone plasmacytoma.
1 patient with acute non-lymphoblastic leukemia
1 patient with acute lymphoblastic leukemia
2 patients with chronic myeloid leukemia
1 patient with chronic lymphatic leukemia
There was only one case which has AML that had the monosomy 7, mean while only one case which has ALL that had the trisomy 8
The current study suggests that , monosomy 7 is present only in the myeloid lineages and not present in lymphoproliferative disorders.
The cytogenetic abnormalities can be characterized as changes involving chromosome number or chromosome structure.
M onosomy 7 and trisomy 8 are two of the most common numerical a bnormalities in hematological neoplasia.
The study aimed at studying the lineage involved by the monosomy 7
and the trisomy 8
The work was performed on 10 patients at diagnosis before initiating therapy : 4 patients with non-Hodgkin's lymphoma
1 patient with solitary bone plasmacytoma.
1 patient with acute non-lymphoblastic leukemia
1 patient with acute lymphoblastic leukemia
2 patients with chronic myeloid leukemia
1 patient with chronic lymphatic leukemia
There was only one case which has AML that had the monosomy 7, mean while only one case which has ALL that had the trisomy 8
The current study suggests that , monosomy 7 is present only in the myeloid lineages and not present in lymphoproliferative disorders.
Other data
| Title | The Clinical Use of Cytogentics in Hematological Malignancies and Related Disorders | Other Titles | الاستخدام الاكلينيكى لعلم الوراثة الخلوى فى امراض الدم السرطا نية والامراض الاخرى لمتعلقة | Authors | Hesham Kamal Habeeb | Issue Date | 2000 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| هشام كمال حبيب.pdf | 3.37 MB | Adobe PDF | View/Open |
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