SALVAGE PARTIAL LARYNGECTOMY AFTER NON SURGICAL TREATMENT FOR LARYNGEAL CARCINOMA
Hamada Hassan Abdel Aziz;
Abstract
Laryngeal carcinoma is the second most common respiratory cancer after lung cancer. Its incidence is increasing over time.
In this meta-analytical study we try to assess the outcome measures (5-years loco-regional control, 5-years disease-free survival) of conservation laryngeal surgery in comparison with total laryngectomy in managing recurrent laryngeal carcinoma after radio-chemotherapy failure.
Searches for articles published in English language in PubMed (Medline data base) for management of recurrent/persistent laryngeal carcinoma after radio-chemotherapy failure yielded 34 relevant articles, of which only 7 articles were included. The other 27 articles were excluded as it did not fulfill inclusion criteria.
Our results as regarding 5-years loco-regional control rate of partial laryngectomy versus total laryngectomy was 105/122 (86%) and 121/181 (66.9%) respectively.
As regarding 5-years disease-free survival the results of partial laryngectomy versus total laryngectomy was 85/116 (73.3%) and 56/150 (37.3%) respectively.
From these result we conclude that:
Conservation laryngeal surgery is a safe and effective treatment for recurrent localized disease after radiotherapy.
This however is predicated on meticulous patient selection for the most appropriate procedure.
Local control may be achieved without sacrifice of laryngeal function.
Total laryngectomy may be held in reserve as the ultimate option for salvage without compromising ultimate survival.
In this meta-analytical study we try to assess the outcome measures (5-years loco-regional control, 5-years disease-free survival) of conservation laryngeal surgery in comparison with total laryngectomy in managing recurrent laryngeal carcinoma after radio-chemotherapy failure.
Searches for articles published in English language in PubMed (Medline data base) for management of recurrent/persistent laryngeal carcinoma after radio-chemotherapy failure yielded 34 relevant articles, of which only 7 articles were included. The other 27 articles were excluded as it did not fulfill inclusion criteria.
Our results as regarding 5-years loco-regional control rate of partial laryngectomy versus total laryngectomy was 105/122 (86%) and 121/181 (66.9%) respectively.
As regarding 5-years disease-free survival the results of partial laryngectomy versus total laryngectomy was 85/116 (73.3%) and 56/150 (37.3%) respectively.
From these result we conclude that:
Conservation laryngeal surgery is a safe and effective treatment for recurrent localized disease after radiotherapy.
This however is predicated on meticulous patient selection for the most appropriate procedure.
Local control may be achieved without sacrifice of laryngeal function.
Total laryngectomy may be held in reserve as the ultimate option for salvage without compromising ultimate survival.
Other data
| Title | SALVAGE PARTIAL LARYNGECTOMY AFTER NON SURGICAL TREATMENT FOR LARYNGEAL CARCINOMA | Other Titles | الإستئصال الجزئي للحنجرة كجراحة انقاذية بعد فشل العلاج غير الجراحي لسرطان الحنجرة | Authors | Hamada Hassan Abdel Aziz | Issue Date | 2014 |
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