Role of Macrophage Inflammatory Protein -1 alpha in Some Respiratory Tract Disorders in Children
Hayam Mahmoud Fathy El-Gebaly;
Abstract
Asthma is a complex disorder characterized by paroxysmal airways constriction, an increased responsiveness of the airways to inhaled allergens and inflammatory cells infiltrate.
Chemokines are central regulatory molecules in inflammatory, immune, and infectious processes of the lung. They are cytokines that induce chemotaxis inflammatory cells. Abnormal chemokine production may contribute to the pathogenesis of bronchial asthma.
Bronchiolitis in infancy is viewed as a risk factor for childhood asthma, a syndrome characterized by wheezing respiratory distress and the pathologic findings of peribronchial cell infiltration and release of inflammatory mediators.
Bronchial asthma and acute bronchiolitis are responsible for a significant proportion of both acute and chronic illness in childhood.
To assess the role of MIP-1 a in bronchial asthma and acute bronchiolitis 30 children (15 diagnosed as bronchial asthma and 15 as acute bronchiolitis) were enrolled in this study along the period January June /2001. The cases were selected from the internal wards of New Children Hospital, Cairo University.
In addition 15 healthy children with matched age and sex were selected from the outpatient clinic and used as control.
Chemokines are central regulatory molecules in inflammatory, immune, and infectious processes of the lung. They are cytokines that induce chemotaxis inflammatory cells. Abnormal chemokine production may contribute to the pathogenesis of bronchial asthma.
Bronchiolitis in infancy is viewed as a risk factor for childhood asthma, a syndrome characterized by wheezing respiratory distress and the pathologic findings of peribronchial cell infiltration and release of inflammatory mediators.
Bronchial asthma and acute bronchiolitis are responsible for a significant proportion of both acute and chronic illness in childhood.
To assess the role of MIP-1 a in bronchial asthma and acute bronchiolitis 30 children (15 diagnosed as bronchial asthma and 15 as acute bronchiolitis) were enrolled in this study along the period January June /2001. The cases were selected from the internal wards of New Children Hospital, Cairo University.
In addition 15 healthy children with matched age and sex were selected from the outpatient clinic and used as control.
Other data
| Title | Role of Macrophage Inflammatory Protein -1 alpha in Some Respiratory Tract Disorders in Children | Other Titles | دور البروتين الإلتهابى 1- ألفا بالخلايا الأكولة فى بعض أمراض الجهاز التنفسى لدى الأطفال | Authors | Hayam Mahmoud Fathy El-Gebaly | Issue Date | 2002 |
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