Evaluation of Serum 25 hydroxyvitamin D level in Vitiligo Patients Before and after Narrowband UVB

Abstract

Vitiligo is an acquired skin disorder caused by the disappearance of pigment cells from the epidermis that gives rise to well defined white patches which are often symmetrically distributed. It occurs worldwide in about 0.1-2% of different population and it occurs as frequently in males as it does in females. The cause is unknown, but might involve genetic factors, autoimmunity, neurologic factors, toxic metabolites, and lack of melanocyte growth factors. Vitiligo reflects a systemic process that has important implications beyond the skin. These include other autoimmune diseases and ocular and neurological abnormalities. Vitiligo is commonly associated with systemic autoimmune conditions, including hypothyroidism and hyperthyroidism, diabetes mellitus, and Sjogren‟s syndrome