NON OPIOID MANAGEMENT OF ACUTE POSTOPERATIVE PAIN

Abstract

Summary evelopment of chronic postsurgical pain syndromes, hyperalgesia and immunomodulation are some particular concerns as they may be related to opioid exposure, intertwined with patient characteristics and other factors. Application of a multimodal approach, administration of preventive analgesia and paradigm shift in surgical techniques all mandate a revisit of evidence-based perioperative pain management. Inadequate treatment of postoperative pain continues to be an important clinical problem, not only leading to worse outcomes in the immediate postoperative period but also an increased risk for persistent postoperative pain. Multimodal pain management combines the use of different pharmacologic mechanisms of action and additive or synergistic effects, which work by acting at different sites within the central and peripheral nervous system .The goal is to provide optimal pain control, limit the amount of opioids required after surgery, and therefore, decrease their associated adverse effects. Pregabalin is a novel drug in which there has been heightened research interest with respect to its analgesic, sedative, anxiolytic and opioid-sparing effects in various pain settings, including postoperativ