Maternal Serum Amyloid A level in Pregnancies Complicated with Preterm Premature Rupture of Membranes

Abstract

Preterm premature rupture of membranes refers to rupture of fetal membranes before 370/7ths weeks of gestation. Membranes rupture could result from intra amniotic infection especially at earlier gestational ages. Among women with PPROM, clinically evident intra amniotic infection occurs in approximately 15–25% and postpartum infection occurs in approximately 15–20%. The most significant risks to the fetus after PPROM are complications of prematurity (Respiratory distress, sepsis, intra ventricular haemorrhage, and necrotizing enterocolitis are associated with prematurity); also PPROM with intrauterine inflammation has been associated with an increased risk of neurodevelopmental impairment and early gestational age membranes rupture associated with an increased risk of neonatal white matter damage. Serum amyloid A (SAA) is a cytokine-inducible inflammatory acute-phase reactant whose plasma concentrations can exceed 1 mg/ml during an acute-phase response. It is also associated with inflammatory response highly similar to erythrocyte sedimentation rate and C reactive protein. Our study is case-control study conducted in Ain Shams University Maternity Hospital from December 2015 – December 2016 on 58 pregnant women to investigate the association between serum amyloid A, CRP and N/L ratio in pregnancies complicated with preterm premature rupture of membranes.