Effect Of Platelet Rich Fibrin Versus Honey On Cutaneous Wound Healing: Experimental Study
Ebtehal Mahmoud Ismail;
Abstract
Wound healing is a complex dynamic series of events which starts within seconds after the injury with haemostasis, followed by three distinct overlapping phases called inflammation, cell proliferation and remodeling
Platelet rich fibrin (PRF) is the latest development of the platelet concentrates developed by Choukroun et al(7, 8) in France and many studies published its effect in improving the healing of both hard and soft tissue injuries.
Honey contains a variety of dietary nutrients that are useful for good health. It was mentioned in the holy Quran and it was also described as therapy in many Ancient civilizations. Honey also has antimicrobial, anti-inflammatory and antioxidant effects which are great criteria to use for wound healing.
This study was conducted to evaluate and compare the effect of PRF and honey on wound healing in albino rabbits.
Twenty-one New Zealand albino rabbits, 1500 to 2000 grams were used in the experiment.
Three parallel full-thickness skin incisions measuring 3 cm in length(22)with 2 cm space between each, were performed under aseptic conditions on the backs of 21 rabbits.The first wound was on the right side of the rabbit and was left untreated (control group G1). PRF was applied to the middle wound (G2). One ml of pure unheated honey was applied to the wound on the left side (G3)(143). Then all wounds were sutured with 3–0 suturing material.
At each time interval of 3,7 and 14 days postoperatively, seven rabbits were sacrificed by overdose of anesthesia (Ketamine) and tissue biopsies were collected from each wound to be examined.
The study groups (G1, G2 and G3) were then divided into subgroups according to the study durations 3, 7 and 14 days. Three days was coded as subgroup A, 7 as subgroup B
Platelet rich fibrin (PRF) is the latest development of the platelet concentrates developed by Choukroun et al(7, 8) in France and many studies published its effect in improving the healing of both hard and soft tissue injuries.
Honey contains a variety of dietary nutrients that are useful for good health. It was mentioned in the holy Quran and it was also described as therapy in many Ancient civilizations. Honey also has antimicrobial, anti-inflammatory and antioxidant effects which are great criteria to use for wound healing.
This study was conducted to evaluate and compare the effect of PRF and honey on wound healing in albino rabbits.
Twenty-one New Zealand albino rabbits, 1500 to 2000 grams were used in the experiment.
Three parallel full-thickness skin incisions measuring 3 cm in length(22)with 2 cm space between each, were performed under aseptic conditions on the backs of 21 rabbits.The first wound was on the right side of the rabbit and was left untreated (control group G1). PRF was applied to the middle wound (G2). One ml of pure unheated honey was applied to the wound on the left side (G3)(143). Then all wounds were sutured with 3–0 suturing material.
At each time interval of 3,7 and 14 days postoperatively, seven rabbits were sacrificed by overdose of anesthesia (Ketamine) and tissue biopsies were collected from each wound to be examined.
The study groups (G1, G2 and G3) were then divided into subgroups according to the study durations 3, 7 and 14 days. Three days was coded as subgroup A, 7 as subgroup B
Other data
| Title | Effect Of Platelet Rich Fibrin Versus Honey On Cutaneous Wound Healing: Experimental Study | Other Titles | تأثيرالصفائح الدموية الغنية بالليفين مقابل العسل على علاج الجرح الجلدي:دراسة تجريبية | Authors | Ebtehal Mahmoud Ismail | Issue Date | 2017 |
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