Relation betweenGlycated Albumin to Glycated Hemoglobin ratio and high bleeding risk of esophageal varicesin patients with liver cirrhosis

Abstract

Cirrhosis is the end stage of chronic damage to the liver. Portal hypertension commonly accompanies liver cirrhosis with the development of OV and PHG as major complications. Gastrooesophgeal variceal hemorrhage (GOV) is a major complication of portal hypertension resulting from liver cirrhosis. Oesophageal variceal bleeding is one of the most dreaded complications of cirrhosis because of its high mortality. The esophago gastro duodenoscopy (EGD) is the gold standard method for evaluating varices to determine whether a patient should be treated to prevent a first variceal hemorrhage. However, the need for repeating EGD is a burden for the patient with a high cost and a small, but significant, risk of complications. Therefore, many non-invasive or minimally invasive methods have been proposed to evaluate the presence, size of such varices. The aim of this work was to assess the value of GA/HbA1c ratio as a non-invasive predictor of OV and its risk of bleeding. Our study was conducted on 45 cases who presented with established liver cirrhosis of any cause and 15 non hepatic patients as a control group, the history, clinical examination, laboratory investigations, ultrasound examination and UGE was done for all cases, &GA/HbA1c ratio were calculated.