Measurement of Serum Estradiol and Progesterone on Day of HCG Administration in Relation to Pregnancy Rate in IVF Cycles

Abstract

Since infertility represents a major physiological and psychological problem to a growing proportion of the population, governments worldwide are investing heavily in assisted reproductive technology (ART) which has led to significant improvements in our understanding of male/female reproductive systems, gamete preservation and gamete manipulation. ART now accounts for 7% of all births in some developed countries. Worldwide, around 1 million ART treatments are performed each year and over 8 million ART babies have been born worldwide. Progesterone and estradiol (E2) are required for successful conception, both to prepare the endometrium for blastocyst implantation and pregnancy. During IVF cycles, the endometrium and embryo are exposed to supra-physiological concentrations of estradiol and progesterone during ovarian stimulation, which could influence pregnancy outcomes. This study analysed the relationship between serum progesterone & estradiol concentrations on the day of HCG administration in IVF cycle and pregnancy rate in gonadotrophin-releasing hormone agonist protocols. The study was conducted in conducted at Ain Shams University Maternity Hospital, in ART unit from May 2014 till March 2015 including 50 patients undergo IVF as a treatment of infertility.