Pharmacological study of potential effect of chrysin in doxorubicin- induced cadiotoxicity in rats

Abstract

DOX is an effective anthracycline antibiotic used to treat a wide range of cancers, however, its clinical efficacy is limited by dose dependent cardiotoxicity. Chrysin (5, 7-dihydroxyflavone) belongs to flavonoids compounds with promising antioxidant, anti-inflammatory, antiapoptotic effects. The present study was designed to investigate the potential protective effect of chrysin against DOX-induced cardiotoxicity in rats and to elucidate the possible underlying molecular mechanisms via studying its effects on different oxidative stress and apoptotic markers. Besides, the potential roles of MAPKs, NF-κB and AKT pathways in the cardioprotective effects of chrysin were further investigated. The present study was divided into two parts: I) Screening the cardioprotective effect of chrysin against acute DOX cardiotoxicity : animals were divided randomly into five groups and treated for 12 days as follow: chrysin once daily at doses of 25 or 50 mg/kg orally and/or DOX (15 mg/kg; i.p.) on day 12.