Impact of Pre-Hypertension on Left Atrial Size and Function
Mahmoud Ibrahem Mohammad Sakr;
Abstract
Hypertension results in left ventricular hypertrophy and reduced left ventricular diastolic function. It has been established that left atrial volume is a sensitive marker for the severity of diastolic dysfunction. (Tsang et al., 2002).
Even mild hypertension seems to be associated with a reduction in early diastolic filling. This results in augmented late left ventricular diastolic filling due to active atrial contraction and may be the mechanism for the increase in left atrial size (Suzanne et al.,2009)
This study was performed to evaluate the left atrial volume, function and diastolic dysfunction of left ventricle in pre-hypertensive volunteers
The study was cross sectional studyincluded 50 pre-hypertensive subjects and 50 normal controls during the period from December, 2009 to April, 2010. Their ages ranged from 18 to 50 years, males and females were included.
Detailed history and examination were done to rule out the inclusion and exclusion criteria.
Three consecutive days blood pressure measurementsin office setting, 15 after arrival were averaged.
Subjects with systolic blood pressure of 120-139 mm Hg or diastolic blood pressure of 80-89 mm Hg were Pre-hypertensive, those with systolic blood pressure below 120 mmHg and diastolic blood pressure below 80 mmHg, were diagnosed as normotensive controls.
Standard Transthoracic Echocardiogram with continuous one-lead electrocardiographic recording was obtained.
LA diameter, LV septal and posterior wall thicknesses were measured by M-mode.
The left atrial volumes were traced and calculated at each point of the cardiac cycle by means of a modified Simpson method from apical 4- and 2- chamber views. (Cheitlin et al., 2003)
1. Volmax, in ventricular systole just before mitral valve opening.
2. Volp, volume before atrial contraction volumeat P-wave onset on electrocardiography
3. Volmin, after mitral valve closure
From these volumes LA emptying parameters were derived (Erol et al., 2002)
• LA passive emptying volume = Volmax - Volp
• LA active emptying volume = Volp - Volmin
• LA total emptying volume = Volmax - Volmin LA
Even mild hypertension seems to be associated with a reduction in early diastolic filling. This results in augmented late left ventricular diastolic filling due to active atrial contraction and may be the mechanism for the increase in left atrial size (Suzanne et al.,2009)
This study was performed to evaluate the left atrial volume, function and diastolic dysfunction of left ventricle in pre-hypertensive volunteers
The study was cross sectional studyincluded 50 pre-hypertensive subjects and 50 normal controls during the period from December, 2009 to April, 2010. Their ages ranged from 18 to 50 years, males and females were included.
Detailed history and examination were done to rule out the inclusion and exclusion criteria.
Three consecutive days blood pressure measurementsin office setting, 15 after arrival were averaged.
Subjects with systolic blood pressure of 120-139 mm Hg or diastolic blood pressure of 80-89 mm Hg were Pre-hypertensive, those with systolic blood pressure below 120 mmHg and diastolic blood pressure below 80 mmHg, were diagnosed as normotensive controls.
Standard Transthoracic Echocardiogram with continuous one-lead electrocardiographic recording was obtained.
LA diameter, LV septal and posterior wall thicknesses were measured by M-mode.
The left atrial volumes were traced and calculated at each point of the cardiac cycle by means of a modified Simpson method from apical 4- and 2- chamber views. (Cheitlin et al., 2003)
1. Volmax, in ventricular systole just before mitral valve opening.
2. Volp, volume before atrial contraction volumeat P-wave onset on electrocardiography
3. Volmin, after mitral valve closure
From these volumes LA emptying parameters were derived (Erol et al., 2002)
• LA passive emptying volume = Volmax - Volp
• LA active emptying volume = Volp - Volmin
• LA total emptying volume = Volmax - Volmin LA
Other data
| Title | Impact of Pre-Hypertension on Left Atrial Size and Function | Other Titles | أثـر طليـعة إرتفاع ضغط الدم على حجم ووظيفـة الأذيـن الأيسـر | Authors | Mahmoud Ibrahem Mohammad Sakr | Issue Date | 2014 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.