PROGNOSTIC VALUE OF SERUM ALBUMIN LEVEL IN HOSPITALIZED PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA

Abstract

SUMMARY ommunity – acquired pneumonia (CAP) is a serious illness, the commonest infectious cause of death and the 6th leading cause of death among diseases. Up to 40% of adults with CAP require hospital admission, hospital mortality varies between 5% and 12%. Mortality is up to 50% in those admitted in ICU.CAP managed in the community has a Mortality of 1% in outpatient clinics. Certain serum biomarkers have been reported to predict mortality and to indicate the severity of CAP, such as serum albumin. Albumin is the most abundant serum protein produced by the liver, serum albumin plays an important role in maintaining physiological homeostasis including maintenance of normal colloid osmotic pressure and transport of endogenous compound. In clinical practice, the serum level of albumin continues to serve as an important marker for the presence, progress and improvement of many inflammatory disease such as pneumonia. The aim of the present study was to evaluate the prognostic value of serum albumin in community acquired pneumonia. The study will include 50 patients who will be admitted to Abbasia chest hospital with CAP, these patients aged < 18 years who were admitted from community, didn't have any antibiotic C Summary 115 exposure during 14 days before coming to us, presented with anew radiographic infiltrate, and showed at least two compatible clinical symptoms (e.g., body temperature < 38oc, productive cough, chest pain, shortness of breath, crackles on auscultation). All patients will be subjected to the following: 1- Full medical history 2- Clinical examination 3- Laboratory examination including :- - liver function tests - kidney function tests - CBC - ESR - Serum Hs C-Reactive Protein - Sputum analysis - Gram stain - Culture and sensitivity - Serum total protein - Serum albumin - Fasting blood sugar 4- X – rays 5- C.T when needed Summary 116 In this study, regarding demographic data of the cases included, the mean age of the patients was 50.16 years with SD ± 20.33. There was a predominance of males in the current study 82% among cases compared with 18 % females. There was a predominance of smokers 80% of cases compared with 20 % non smokers.