INFLUENCE OF LOW DOSE ORAL CONTRACEPTION IN WOMAN WITH BILHARZIASES ON LIVER FUNCTIONS

Abstract

The liver is affected in more ways and with more regularity and intensity by contraceptive steroids than any other extra - genital organ. Estrogen influence the synthesis of hepatic cell enzymes , the active transport of biliary component is impaired by a large number of estrogens as well as some progestins. The mechanism is unclear but cholestatic jaundice and pruritus are occasional complication of the pill and are similar to the recurrent jaundice of preg. (Speroff, et al. 1978).

200 adult Egyptian females were chosen to study the effects of low dose oral contraceptive pills. on liver function on Bilharzia!women. They were subdivided into 3 groups according to duration of use and to the Bilharzia!affection 200 women were selected for this study for each case a through examination is done to exclude any abnormality , and a venous blood sample was taken centrifuged and the supemant serum was separated for the following investigations.

Serum Bilirubin , Serum albumin , Serum Alkaline phosphatase , Serum transaminase (SGPT and SGOT) , Serum cholesterol , Serum fasting triglycerides , Prothrombin time.

* The level of serum albumin shows statistically significant decrease in group

B & C but still in the normal range for the method of determination.

* The level of serum bilirubin shows insignificant changes.

* The level of alkaline phosphatase shows insignificant changes.