Effect of green tea and high protein diets supplemented with fish oil on weight reduction of obese rats.

Abstract

Obesity is a worldwide problem. It is tightly associated with dyslipidemia, type 2 diabetes and cardiovascular diseases, all posing huge threats to human health. The n-3 polyunsaturated fatty acids (PUFA), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are known as anti-obesity factors. Fish oil containing high concentrations of DHA and EPA is considered a good source of these n-3 PUFA. One of the major concerns related to the increasing obesity incidence is its association with other pathological signs, including hypertension, dyslipidemia, insulin resistance, and glucose intolerance. The combination of these features constitutes the so-called metabolic syndrome that dramatically increases the risk to develop cardiovascular disease or diabetes.

The major effects of n-3 PUFA on modulating lipid metabolism are to promote lipolysis and fatty acid oxidation and to inhibit lipogenesis. Treatments with DHA increase glycerol release, an indicator of lipolysis in murine and human adipocytes. Green tea catechins GTCs with caffeine is associated with statistically significant reductions in BMI, body weight, and waist circumference WC; however, the clinical significance of these reductions is modest at best. Current data do not suggest that GTCs alone positively alter anthropometric measurements.

The main target of the present work will be studied the effect of low and high protein diet in the presence of green tea and fish oil on rats suffering from obesity.

Green tea and fish oil were obtained from local market, Cairo, Egypt were investigated on the Serum Cholesterol, Serum Triglycerides, High density lipoprotein cholesterol, low density lipoprotein cholesterol and very low density lipoprotein cholesterol. This work was carried out on male albino rats sprague Dawley Strain (70 rats) after adaptation period, the rats were divided into three main groups different percentages of protein and 8 subgroups different percentages of green tea and fish oil. The obtained results could be summarized in the main following point.