Isosorbide Mononitrate versus Prostaglandins for Pre-induction of Labor at Term Pregnancy
Mohamed Mohamed Al-Saeed;
Abstract
Summary
t is now generally accepted that the uterine cervix plays an important role during pregnancy and labor and that it depends on an active ripening process within the cervix. Which is necessary for successful labor induction.
Different methods of cervical ripening have been used including non pharmacological methods as breast stimulation, membrane stripping and amniotomy, pharmacological methods including estradiol, oxytocin, prostaglandins and prostaglandin analogues have been tried.
The ideal cervical ripening agent would include cervical remodeling without stimulating uterine activity and nitric oxide donors are such agents. Prostaglandin agents namely Dinoprostone thought effective are associated with side effects such as hyperstimulation and Tachysystole also vomiting, nausea, diarrhea.
The objective of this study was to compare the effectiveness and safety of IMN versus Dinoprostone for cervical ripening and induction of labor in full term pregnancy.
In this study 100 pregnant females were included for induction of labor. They were divided into two groups each of 50 female. One group received 40mg IMN and the other group received 3 mg Dinoprostone, both were applied in
I
Summary
107
posterior vaginal fornix, oxytocin was used as hospital protocol for induction of labor.
There was no significant difference regarding the mode of delivery whether vaginal or cesareans section in both groups.
Regarding the time needed for vaginal delivery between the two groups it was found that time in Dinoprostone group was shorter than time in IMN group.
Regarding oxytocin requirement it was more required in IMN group than in Dinoprostone group.
Regarding indication of cesarean section, Dystocia was more frequent in IMN while non reassuring FHR was more frequent in Dinoprostone group.
Regarding the adverse effects Tachysystole and hyperstimulation were more frequent in Dinoprostone group while headach, nausea, vomiting,dizziness, hypotension were more frequent in IMN group.
Regarding NICU requirement there were no significant between IMN and Dinoprostone group.
The result suggested that IMN less effective than Dinoprostone but with a fewer adverse effects.
t is now generally accepted that the uterine cervix plays an important role during pregnancy and labor and that it depends on an active ripening process within the cervix. Which is necessary for successful labor induction.
Different methods of cervical ripening have been used including non pharmacological methods as breast stimulation, membrane stripping and amniotomy, pharmacological methods including estradiol, oxytocin, prostaglandins and prostaglandin analogues have been tried.
The ideal cervical ripening agent would include cervical remodeling without stimulating uterine activity and nitric oxide donors are such agents. Prostaglandin agents namely Dinoprostone thought effective are associated with side effects such as hyperstimulation and Tachysystole also vomiting, nausea, diarrhea.
The objective of this study was to compare the effectiveness and safety of IMN versus Dinoprostone for cervical ripening and induction of labor in full term pregnancy.
In this study 100 pregnant females were included for induction of labor. They were divided into two groups each of 50 female. One group received 40mg IMN and the other group received 3 mg Dinoprostone, both were applied in
I
Summary
107
posterior vaginal fornix, oxytocin was used as hospital protocol for induction of labor.
There was no significant difference regarding the mode of delivery whether vaginal or cesareans section in both groups.
Regarding the time needed for vaginal delivery between the two groups it was found that time in Dinoprostone group was shorter than time in IMN group.
Regarding oxytocin requirement it was more required in IMN group than in Dinoprostone group.
Regarding indication of cesarean section, Dystocia was more frequent in IMN while non reassuring FHR was more frequent in Dinoprostone group.
Regarding the adverse effects Tachysystole and hyperstimulation were more frequent in Dinoprostone group while headach, nausea, vomiting,dizziness, hypotension were more frequent in IMN group.
Regarding NICU requirement there were no significant between IMN and Dinoprostone group.
The result suggested that IMN less effective than Dinoprostone but with a fewer adverse effects.
Other data
| Title | Isosorbide Mononitrate versus Prostaglandins for Pre-induction of Labor at Term Pregnancy | Other Titles | المقارنة بين استخدام أيزوسوربيد أحادى النيترات والبروستاجلاندين لإنضاج عنق الرحم قبل التحريض على الولادة فى حالات الحمل المكتمل | Authors | Mohamed Mohamed Al-Saeed | Issue Date | 2015 |
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