Vaginal Fluid Prolactin in Cases of Suspected Prelabour Rupture of Fetal Membranes
Mohamed Mansour Fathi Elsebaei;
Abstract
This is a prospective observational study , carried out in Ain Shams Universtiy Maternity Hospital. A total of 180 pregnant women were included in the study, between 28-40weeks of gestation, divided into three groups:
Group 1: It included 60 pregnant women between 28-40 weeksof gestation (suspicious group).
Group 2: it included 60 pregnant women between 28-40 weeks of gestation (confirmed group).
Group 3: it included 60 pregnant women between 28-40 weeks of gestation (control group).
At admission, all women underwent sterile cusco speculum examination and amniotic fluid pooling with or without valsalva maneuver was noted.
After giving an informed consent, 5 ml of sterile saline solution was injected in the posterior vaginal fornix using a sterile cusco speculum and 3 ml of the injected saline was withdrawn with the same syringe and it was sent immediately to the laboratory for assay of prolactin hormone. This was followed by ultrasonic assessment of amniotic fluid index for all women.
Then all patients were followed up until delivery and gestational age at delivery time was documented. The parameters (age, parity, gestational age at delivery, time interval between sampling and delivery, fetal weight, APGAR score after 1 minute and 5 minutes) were also documented.
The study was concluded to assess the reliability of vaginal fluid prolactin assay for the diagnosis of prelabour rupture of membranes and to determine a diagnostic cut-off value.
The current study showed that there is a high statistically significant difference between the three studied groups as regards gestational age at delivery and interval period. On the other hand there is no significant statistical difference could be detected between the studied groups as regards maternal age.
Group 1: It included 60 pregnant women between 28-40 weeksof gestation (suspicious group).
Group 2: it included 60 pregnant women between 28-40 weeks of gestation (confirmed group).
Group 3: it included 60 pregnant women between 28-40 weeks of gestation (control group).
At admission, all women underwent sterile cusco speculum examination and amniotic fluid pooling with or without valsalva maneuver was noted.
After giving an informed consent, 5 ml of sterile saline solution was injected in the posterior vaginal fornix using a sterile cusco speculum and 3 ml of the injected saline was withdrawn with the same syringe and it was sent immediately to the laboratory for assay of prolactin hormone. This was followed by ultrasonic assessment of amniotic fluid index for all women.
Then all patients were followed up until delivery and gestational age at delivery time was documented. The parameters (age, parity, gestational age at delivery, time interval between sampling and delivery, fetal weight, APGAR score after 1 minute and 5 minutes) were also documented.
The study was concluded to assess the reliability of vaginal fluid prolactin assay for the diagnosis of prelabour rupture of membranes and to determine a diagnostic cut-off value.
The current study showed that there is a high statistically significant difference between the three studied groups as regards gestational age at delivery and interval period. On the other hand there is no significant statistical difference could be detected between the studied groups as regards maternal age.
Other data
| Title | Vaginal Fluid Prolactin in Cases of Suspected Prelabour Rupture of Fetal Membranes | Other Titles | برولاكتين السائل المهبلي في حالات الاشتباه في تمزق الأغشية الجنينية قبل الولادة | Authors | Mohamed Mansour Fathi Elsebaei | Issue Date | 2015 |
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