Study of Serum Presepsin as Diagnostic &Prognostic Marker in Early Onset Neonatal Sepsis
Hoda Mostafa Nagi El-sayed;
Abstract
Summary
N
eonatal sepsis still remains a major cause of morbidity and mortality in neonatal intensive care unit (NICU).
The accurate diagnosis of sepsis is one of the main challenges in emergency medicine as early recognition and appropriateness of therapy in the initial hours after presentation considerably influences the outcomes of septic patients.
As a result, great effort to reduce the neonatal mortality rate is put into looking for new reliable biomarkers
Blood culture is the gold standard method for detecting micro-organisms but it requires too much time for results to be known. CRP is one of the acute phase proteins synthesized by the liver; it has a great sensitivity but a very poor specificity for bacterial infections. Moreover, the evolution of sepsis does not correlate with CRP plasma changes.
CD14 is a membrane glycoprotein of monocytes/macrophages (mCD14) and serves as a pattern recognition moleclue in the innate immune response against microorganism. Upon activation of proinflammatory signaling cascade by CD14 is shedded of from the cell membrane resulting in soluble CD14 (sCD14). Plasma protease activity generates also another particle from sCD14 called sCD14 subtype (sCD14-ST) presepsin.
Presepsin is a novel and promising biomarker that has been shown to increase significantly in adults with sepsis, in comparison to the healthy adults. Studies pointed out the capability of this biomarker for diagnosing sepsis, assessing the severity of the disease and providing a prognostic evaluation of patient outcome.
The aim of this study was to evaluate the efficacy of presepsin in both diagnosis and prognosis of early-onset neonatal sepsis in full term neonates.
N
eonatal sepsis still remains a major cause of morbidity and mortality in neonatal intensive care unit (NICU).
The accurate diagnosis of sepsis is one of the main challenges in emergency medicine as early recognition and appropriateness of therapy in the initial hours after presentation considerably influences the outcomes of septic patients.
As a result, great effort to reduce the neonatal mortality rate is put into looking for new reliable biomarkers
Blood culture is the gold standard method for detecting micro-organisms but it requires too much time for results to be known. CRP is one of the acute phase proteins synthesized by the liver; it has a great sensitivity but a very poor specificity for bacterial infections. Moreover, the evolution of sepsis does not correlate with CRP plasma changes.
CD14 is a membrane glycoprotein of monocytes/macrophages (mCD14) and serves as a pattern recognition moleclue in the innate immune response against microorganism. Upon activation of proinflammatory signaling cascade by CD14 is shedded of from the cell membrane resulting in soluble CD14 (sCD14). Plasma protease activity generates also another particle from sCD14 called sCD14 subtype (sCD14-ST) presepsin.
Presepsin is a novel and promising biomarker that has been shown to increase significantly in adults with sepsis, in comparison to the healthy adults. Studies pointed out the capability of this biomarker for diagnosing sepsis, assessing the severity of the disease and providing a prognostic evaluation of patient outcome.
The aim of this study was to evaluate the efficacy of presepsin in both diagnosis and prognosis of early-onset neonatal sepsis in full term neonates.
Other data
| Title | Study of Serum Presepsin as Diagnostic &Prognostic Marker in Early Onset Neonatal Sepsis | Other Titles | دراسة مستوى البريسيبسين وقيمته التشخيصية والتنبؤية في حالات تسمم الدم المبكر لدى حديثى الولادة | Authors | Hoda Mostafa Nagi El-sayed | Issue Date | 2017 |
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