Alpha-1-Acid Glycoprotien for Early diagnosis of Neonatal Sepsis in Neonate

Abstract

Neonatal sepsis remains a major clinical problem in neonatology, with high morbidity and mortality rates despite the progress in neonatal intensive care and antibiotics. The host defense against infections is immature in the newborn infant, and this makes the neonate more susceptible to intensive infection. The diagnosis of neonatal sepsis begins with clinical suspicion. The challenge for the neonatal practitioner is to decide which babies need empirical antibiotic therapy but this causes antibiotic overuse and nosocomial infections because of unnecessary hospitalization. Unfortunately there is no single diagnostic test, which can reliably diagnose sepsis in the newborn, therefore many diagnostic tests are utilized to diagnose or confirm sepsis. This study was conducted in order to evaluate the diagnostic value of α-1-acid glycoprotein in the early diagnosis of neonatal sepsis. Neonates included in the study were be enlisted to one of 3 groups, laboratory septic group which include 24 neonates admitted to neonatal intensive care unit (NICU) with sepsis proved with chemical & laboratory investigations, Clinically septic group which include 24 neonates admitted to NICU with clinical manifestation of sepsis, control group which include 24 full healthy neonate as a control group. All the study population were subjected to the following: 1.History taking. 2.Clinical examination. 3. Laboratory Investigations including:  Complete blood count. Summary and Conclusion  104  Blood cultures for isolation of the causative organism and its identification.  Quantitative measurement of CRP.  Quantitative measurement of α-1-acid glycoprotein by immunoturbidimetry. Poor reflexes, lethargy and respiratory distress were the commonest presentation of sepsis in our study followed by GIT manifestations and temperature instability, while sclerema and covultions were the least presentation of sepsis. Our study reveals no significant difference reNeonatal sepsis remains a major clinical problem in neonatology, with high morbidity and mortality rates despite the progress in neonatal intensive care and antibiotics. The host defense against infections is immature in the newborn infant, and this makes the neonate more susceptible to intensive infection. The diagnosis of neonatal sepsis begins with clinical suspicion. The challenge for the neonatal practitioner is to decide which babies need empirical antibiotic therapy but this causes antibiotic overuse and nosocomial infections because of unnecessary hospitalization. Unfortunately there is no single diagnostic test, which can reliably diagnose sepsis in the newborn, therefore many diagnostic tests are utilized to diagnose or confirm sepsis. This study was conducted in order to evaluate the diagnostic value of α-1-acid glycoprotein in the early diagnosis of neonatal sepsis. Neonates included in the study were be enlisted to one of 3 groups, laboratory septic group which include 24 neonates admitted to neonatal intensive care unit (NICU) with sepsis proved with chemical & laboratory investigations, Clinically septic group which include 24 neonates admitted to NICU with clinical manifestation of sepsis, control group which include 24 full healthy neonate as a control group. All the study population were subjected to the following: 1.History taking. 2.Clinical examination. 3. Laboratory Investigations including:  Complete blood count. Summary and Conclusion  104  Blood cultures for isolation of the causative organism and its identification.  Quantitative measurement of CRP.  Quantitative measurement of α-1-acid glycoprotein by immunoturbidimetry. Poor reflexes, lethargy and respiratory distress were the commonest presentation of sepsis in our study followed by GIT manifestations and temperature instability, while sclerema and covultions were the least presentation of sepsis. Our study