Study of Cardiac Functions in children with Congenital Adrenal Hyperplasia
Mai Nouby Shahat;
Abstract
SUMMARY
C
ongenital adrenal hyperplasia (CAH) is one of the most frequent congenital endocrine disorders; it comprises autosomal recessive disorders of cortisol biosynthesis in the adrenal gland caused by various enzyme deficiencies. The consequent compensatory rise of ACTH production causes hyperplastic growth of the adrenal glands.
Treatment of CAH aims to reduce excessive androgen secretion by replacing the deficient hormones, where proper treatment with GCs and MCs prevents adrenal crisis and virilization, allowing normal growth and development.
This study aimed to assess echo-cardiographic functions in children with congenital adrenal hyperplasia receiving corticosteroid therapy for a time interval ranging from two to four years.
The present study has been conducted on twenty-one patients with congenital adrenal hyperplasia following up at the Paediatric Endocrinology Clinic of Ain-Shams University Hospitals.
Patients were subjected to a detailed history taking and examination, anthropometric evaluation, Tanner staging, hormonal assay for androgen profile, Karyotyping, molecular study and echo-cardiograhic examination.
Results of this study showed that:
C
ongenital adrenal hyperplasia (CAH) is one of the most frequent congenital endocrine disorders; it comprises autosomal recessive disorders of cortisol biosynthesis in the adrenal gland caused by various enzyme deficiencies. The consequent compensatory rise of ACTH production causes hyperplastic growth of the adrenal glands.
Treatment of CAH aims to reduce excessive androgen secretion by replacing the deficient hormones, where proper treatment with GCs and MCs prevents adrenal crisis and virilization, allowing normal growth and development.
This study aimed to assess echo-cardiographic functions in children with congenital adrenal hyperplasia receiving corticosteroid therapy for a time interval ranging from two to four years.
The present study has been conducted on twenty-one patients with congenital adrenal hyperplasia following up at the Paediatric Endocrinology Clinic of Ain-Shams University Hospitals.
Patients were subjected to a detailed history taking and examination, anthropometric evaluation, Tanner staging, hormonal assay for androgen profile, Karyotyping, molecular study and echo-cardiograhic examination.
Results of this study showed that:
Other data
| Title | Study of Cardiac Functions in children with Congenital Adrenal Hyperplasia | Other Titles | دراسة وظائف القلب فى الأطفال المصابين بمرض فرط تنسج الغدة الكظرية الوراثى | Authors | Mai Nouby Shahat | Issue Date | 2017 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.