Impact of Remote Ischemic Post-Conditioning on Lv Remodeling in Patients With Anterior St-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Abstract

SUMMARY S T elevation myocardial infarction (STEMI) is by far the most serious presentation of atherosclerotic coronary artery disease, carrying the most hazardous consequences. Patients with STEMI are triaged immediately for reperfusion therapy. The current PCI guidelines recommend that primary PCI should be performed in patients with STEMI who present within 12 hours of symptom onset. Reperfusion methods for STEMI have evolved greatly in the past decades, it was first only restricted to medical treatment including fibrinolytics. But since the start of the era of PCI, significant changes and upgrades in methods of reperfusion appeared to the surface, altering significantly morbidity and mortality rates of STEMI. Although primary angioplasty has reduced the risk of mortality as compared with fibrinolysis in ST elevation myocardial infarction, left ventricular (LV) dysfunction still occurs in many patients. (Keeley et al, 2003). Rapid restoration of blood flow can cause ischemic reperfusion injury, which sometimes has a fatal outcome. It was proven to have a significant negative effect that may limit the total benefit of Primary PCI in general. In pre-clinical studies, the impact of myocardial reperfusi